佰乐博生物代理AntibodySystem，InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0255)体内中和抗体，活性抗体

标题：佰乐博生物代理AntibodySystem，InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0255)体内中和抗体，活性抗体

名称：InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0255)体内中和抗体，活性抗体

别名：C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1

货号：VME85601

宿主：Mouse

适用物种：Mouse

存储缓冲区：0.01M PBS, pH 7.4.

形式：Liquid

纯度：>95%

克隆：Monoclonal

同型：IgG2a, kappa

应用：ELISA, Neutralization

内毒素水平：Please contact with the lab for this information.

UniProt：P56484

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

 

参考文献：

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. PMID: 35140181

Chemokine Receptor-Targeted Therapies: Special Case for CCR8. PMID: 35158783

Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody. PMID: 36352891

S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells. PMID: 37420296

Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function. PMID: 35973731

CD4(+)CCR8(+) Tregs in ovarian cancer: a potential effector Tregs for immune regulation. PMID: 37950246

Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation. PMID: 37770937

The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer. PMID: 35354899

TGF-beta-induced CCR8 promoted macrophage transdifferentiation into myofibroblast-like cells. PMID: 35377281

CCR8 as a Therapeutic Novel Target: Omics-Integrated Comprehensive Analysis for Systematically Prioritizing Indications. PMID: 38001911

CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-gamma Producing Innate Lymphoid CelIs and Protects From Experimental Colitis. PMID: 33613532

CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer. PMID: 32367308

Role of chemokines in the crosstalk between tumor and tumor-associated macrophages. PMID: 36173487

The Chemokine Receptor CCR8 Is a Target of Chimeric Antigen T Cells for Treating T Cell Malignancies. PMID: 35693763