Research Grade Ramatercept

Research Grade Ramatercept

一、中文名称：Research Grade Ramatercept，研究级Ramatercept类似物

 

二、产品描述

Ramatercept (ACE-031) 是MSTN 抑制剂(生长分化因子-8 抑制剂)，也是一种可溶的 ActRIIB 受体，能作为可溶性激活素受体 2 (ACVR2) 拮抗剂。Ramatercept 抑制肌生长抑制信号通路，在肌萎缩中有潜在应用。。

 

三、产品详情

名称：Research Grade Ramatercept (DHA30606)

别名：ACE-031,ActRIIB-IgG1,ActRIIb:Fc Fusion Protein,HGT-4510,RAP-031, CAS: 1169766-01-1

货号：DHA30606

表达系统：Mammalian Cells

种属反应性：Human

同种型：Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant)

靶标：GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8

浓度：1 mg/ml

内毒素水平：Please contact with the lab for this information.

纯度：>95% as determined by SDS-PAGE.

纯化方式：Protein A/G purified from cell culture supernatant.

Accession号：O14793

克隆号：Ramatercept

应用：Research Grade Biosimilar

状态：Liquid

保存溶液：0.01M PBS, pH 7.4.

稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

 

四、参考文献：

Viscera Characteristics of MSTN-Edited Heterozygous Pigs.PMID:35299949

MSTN modification in goat mediated by TALENs and performance analysis.PMID:35729101

Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: A Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation.PMID:36360291

MSTN Regulatory Network in Mongolian Horse Muscle Satellite Cells Revealed with miRNA Interference Technologies.PMID:36292721

Differential Expression of MSTN Isoforms in Muscle between Broiler and Layer Chickens.PMID:35268106

A MSTN(Del73C) mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia.PMID:39365728

Germline transmission of MSTN knockout cattle via CRISPR-Cas9.PMID:36037573

Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction.PMID:33938454

Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.PMID:38889010

Reproduction and viscera organ characteristics of MSTN and FGF5 dual-gene knockout sheep.PMID:37065235

 

详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司

 

武汉佰乐博生物技术有限公司作为法国Antibodysystem品牌亚洲区授权总代理。提供近3万种蛋白、抗体等核心生命科学试剂，旨在为生命科学科研工作者提供专业、全面、可靠的试剂产品。

试剂 | 耗材 | 定制 | 实验服务 | 供应链

免费热线：027-65279366 /18108604356