Research Grade Recifercept

Research Grade Recifercept

一、中文名称：

Research Grade Recifercept，科研级Recifercept

二、产品描述

人成纤维细胞生长因子受体 3（FGFR - 3，又名 CD333 ），是 Research Grade Recifercept 的关键靶标。作为受体酪氨酸激酶家族的跨膜蛋白，FGFR - 3 在多种组织细胞中表达，关键调控细胞生长、分化、增殖及组织发育修复。生理状态下，FGFR - 3 与 FGF1、FGF2 等 FGFs 家族成员特异性结合，激活 RAS - RAF - MEK - ERK 和 PI3K - AKT 等信号通路，调节细胞行为。如在骨骼发育时，它调控软骨细胞，对骨骼生长塑形意义重大。然而，FGFR - 3 及其信号通路异常会引发严重疾病。遗传性骨骼疾病如软骨发育不全症，因 FGFR - 3 基因激活突变，受体持续活化，过度抑制软骨细胞增殖，导致患者四肢短小、身材矮小。肿瘤方面，FGFR - 3 异常表达激活与多种癌症相关，像膀胱癌中促癌增殖、侵袭、转移及抗凋亡，多发性骨髓瘤中促进骨髓瘤细胞存活生长，关联疾病复发与不良预后。

三、产品详情

名称：Research Grade Recifercept，科研级Recifercept

货号: DHC15701,

表达系统: Mammalian Cells,

种属反应性: Human,

同种型: Human Fibroblast Growth Factor receptor 3 (FGFR-3, CD333),

克隆类型: Monoclonal,

靶标: FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF10, FGF17, FGF18, FGF19, FGF20 and FGF23,

浓度: 1 mg/ml,

内毒素水平: Please contact with the lab for this information.,

纯度: >95% as determined by SDS-PAGE,

纯化方式: Protein A/G purified from cell culture supernatant,

克隆号: Recifercept,

应用: Research Grade Biosimilar,

状态: Liquid,

保存溶液: 0.01M PBS, pH 7.4,

稳定性和存储: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term,

别名: PF-07256472, Reciferecept, TA-46

四、参考文献：

Juvenile toxicity study of PF-07256472/recifercept, a recombinant human soluble fibroblast growth factor receptor 3, in 2-3-month-old cynomolgus monkeys.PMID:36367445

In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia.PMID:33370388

Longitudinal Imaging of the Skull Base Synchondroses Demonstrate Prevention of a Premature Ossification After Recifercept Treatment in Mouse Model of Achondroplasia.PMID:35229060

Natural disease course modeling of achondroplasia to evaluate the efficacy of recifercept in the absence of a placebo control arm in phase II study.PMID:38685585

Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model.PMID:39185375

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