Research Grade Abatacept (DHE03429)

Research Grade Abatacept (DHE03429)

一、中文名称：Research Grade Abatacept (DHE03429)，研究级Abatacept类似物

 

二、产品描述

Abatacept (CTLA4lg) 是一种可溶性融合蛋白，由人 CTLA4 的胞外结构域和人 IgG1 Fc 部分的片段 (铰链，CH2 和 3 结构域) 组成。Abatacept 是选择性 T 细胞共刺激调节剂，也是一种用于自身免疫性疾病的蛋白活性分子。

 

三、产品详情

名称：Research Grade Abatacept (DHE03429)

货号：DHE03429

表达系统：Mammalian Cells

种属反应性：Human

宿主：Human

同种型：IgG1-Fc

克隆类型：Monoclonal

靶标：CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1, BU63, B70, CD28LG2, CTLA-4 counter-receptor B7.2, Activation B7-2 antigen, T-lymphocyte activation antigen CD86, CD86, FUN-1

浓度：2.29 mg/ml

内毒素水平：Please contact with the lab for this information.

纯度：>95% as determined by SDS-PAGE.

纯化方式：Protein A/G purified from cell culture supernatant.

Accession号：P33681 &/or P42081

克隆号：Abatacept

应用：Research Grade Biosimilar

状态：Liquid

保存溶液：0.01M PBS, pH 7.4.

稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

 

四、参考文献：

Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis.PMID:33053283

Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.PMID:33449816

Abatacept for the treatment of rheumatoid arthritis.PMID:30730220

Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial.PMID:38364839

Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial.PMID:36920087

Abatacept in early polymyalgia rheumatica (ALORS): a proof-of-concept, randomised, placebo-controlled, parallel-group trial.PMID:38251563

Abatacept: A Review in Rheumatoid Arthritis.PMID:28608166

Reversal of immune-checkpoint inhibitor fulminant myocarditis using personalized-dose-adjusted abatacept and ruxolitinib: proof of concept.PMID:35383117

[Abatacept].PMID:27311187

Abatacept: A Review of the Treatment of Polyarticular-Course Juvenile Idiopathic Arthritis.PMID:33029724

How does abatacept really work in rheumatoid arthritis?PMID:29401118

Abatacept-Induced Disseminated Superficial Porokeratosis.PMID:33337807

Abatacept for acute graft-versus-host disease prophylaxis after unrelated donor hematopoietic cell transplantation.PMID:39028876

详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司

 

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